Paludan – pharmacological drug belonging to the group of adjuvants. It is used for the treatment of ocular viral diseases.

The composition and form of issue

Poludan is produced in the form of a white lyophilisate, intended to prepare the solution.

Active substances of this drug are poliribonat polyribosyl potassium and potassium. As auxiliary components this drug contains potassium dihydrophosphate, sodium hydrogen phosphate, sodium chloride.

The lyophilisate is packaged in glass ampoules in a volume of 1 ml or vials in a volume of 5 ml. Carton contains 10 ampoules or 10 bottles, plus a leaflet with instructions for use.

Cardboard packaging with the vials also contains a special ampoule scarifier or knife.

Pharmacological action

A basic property of Poludana is its immunostimulatory effects on the human body. This drug belongs to polyribonucleotide biosynthetic complexes, which enhances the synthesis of endogenous interferon.

Moreover, Poludan has immunomodulatory and antiviral effect, increases the level of activity of immunocompetent cells.


When subconjunctival administration this drug increases the production of interferon in lacrimal fluid and blood serum.

Indications for use

Poludan is assigned to the following viral therapy of eye diseases in children and adults:

Contraindications to the use of

Protivopokazanii, for the purpose and use of the drug is individual hypersensitivity to any of its ingredients.

In addition, it is not recommended to apply this medication for the treatment of keratouveitis with ulceration of the cornea, in particular the front surface thereof, and for the treatment of conjunctivitis with presence of pathogenic microorganisms in the seeding of the conjunctiva.

Poludan is not used for administration during infectious diseases of the paranasal sinuses (e.g., sinusitis, sinusitis and other diseases) and teeth.

Methods of application and doses

The introduction of Poludana is carried out and by periocular subconjunctival and anterior eye chamber.

Immediately before use of the drug contents of the vial or ampoule should be diluted in 1 ml of sterile water for injection or 1 ml of 0.5% solution of novocaine.

The drug is injected under the conjunctiva once a day every day or every other day.

The course of treatment lasts from five to twenty days in direct proportion to the individual readings.

In childhood, subkonyunktivalno Paludan is applied in a volume of 0.25 ml of the prepared solution every other day. The course of treatment lasts not more than eight days.

When endotelialnah the form of keratomalacia ready solution of the drug is injected into the anterior eye chamber with the help of tuberculin syringe, this procedure is performed exclusively in the operating room of the house. The volume of injection solution is 0,3-0,6 ml. the Introduction is carried out twice a week for one course of therapy is 3-5 injections.

Uveitis, herpetic chorioretinitis and optic neuritis treated with drug administration by periocular (i.e., parabulbarno or retrobulbarno). While the volume of injected solution is 1 ml, the procedure is carried out once in two days. For injection, the lyophilisate of the preparation diluted in 1 ml purified water or 0.5% solution of novocaine.

With the appearance of fresh herpes lesions of herpes zoster on the face, while HSV lesion of the cornea, is the hypodermic injection of this drug. For this treatment the contents of two vials or ampoules is dissolved in 10-20 ml of 0.5% solution of novocaine. Subcutaneous injections are made in this case in the course of herpetic vesicles.

This procedure is repeated through the day. While there is a significant decrease in pain intensity and the onset of rapid recovery.

One course of therapy, usually have from three to six injection treatments.

Полудан способ применения

Side effects

According to numerous reviews about the drug patients, it can very rarely cause allergic reactions.

When the subconjunctival method of its use may appear slight swelling of the lower eyelid and intensify the injection of the vessels of the conjunctiva.

With the introduction of this drug in the anterior eye chamber, possibly a transient increase in intraocular pressure, as well as the appearance of petechial hemorrhaging in the anterior chamber of the eye.

Interaction with other drugs

Poludan is not recommended for joint use with enzyme drugs because they contribute to the destruction of endogenous interferon, and therefore reduce the effectiveness of Poludana.

However, this drug is easily combined with antibiotics and antiviral drugs, not engaging with them in response, and, accordingly, without influencing their effectiveness.

Special instructions

Any side adverse reactions that can occur with this drug are short lived and usually disappear independently after (not more than one to three days) drug withdrawal or at the end of therapy.

Полудан особые указания

Terms and conditions of storage

Store this medication need in a cool place, at temperature not above +4°C. it is also important to store the drug in a child proof, moisture and direct sunlight. The shelf life of the lyophilisate is 4 years from the date of the release of his production, provided hermeticity of the package. After the expiration date the drug use is not subject.

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